THE DEFINITIVE GUIDE TO TRASTUZUMAB MONITORING

The phosphorylated HER3 provides docking websites for p85 subunit of PI3K. The absolutely activated PI3K complicated is generated by binding of p110 subunit of PI3K to p85 which is able to deliver PIP3 via phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at each threonine and serin phospho